Substrate specificity and structure-activity relationships of gentamicin acetyltransferase I. The dependence of antibiotic resistance upon substrate Vmax/Km values.
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منابع مشابه
Substrate specificity and structure-activity relationships of gentamicin acetyltransferase I. The dependence of antibiotic resistance upon substrate Vmax/Km values.
Sixteen aminoglycoside antibiotics and derivatives were found to be substrates and nine were identified as competitive inhibitors of purified gentamicin acetyltransferase I. Among the substrates, gentamicin A, kanamycin B, tobramycin, neamine, nebramine (tobramine), and gentamine Cl, were previously questioned on the basis of results obtained from microbiological studies or enzymatic experiment...
متن کاملSubstrate Specificity and Structure-Activity Relationships of Gentamicin Acetyltransferase I THE DEPENDENCE OF ANTIBIOTIC RESISTANCE UPON SUBSTRATE
Sixteen aminoglycoside antibiotics and derivatives were found to be substrates and nine were identified as competitive inhibitors of purified gentamicin acetyltransferase I. Among the substrates, gentamicin A, kanamycin B, tobramycin, neamine, nebramine (tobramine), and gentamine Cl, were previously questioned on the basis of results obtained from microbiological studies or enzymatic experiment...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1978
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)34554-4